@article {3132735,
	title = {UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems},
	journal = {Mol Cell},
	volume = {72},
	number = {3},
	year = {2018},
	note = {1097-4164Malcov-Brog, HagarAlpert, AyeletGolan, TamarParikh, ShivangNordlinger, AliceNetti, FrancescaSheinboim, DannaDror, IrisThomas, LaetitiaCosson, CamilleGonen, PinchasStanevsky, YuryBrenner, RonenPerluk, TomerFrand, JacobElgavish, SharonaNevo, YuvalRahat, DolevTabach, YuvalKhaled, MehdiShen-Orr, Shai SLevy, Carmit726225/ERC_/European Research Council/InternationalJournal ArticleResearch Support, Non-U.S. Gov{\textquoteright}tMol Cell. 2018 Nov 1;72(3):444-456.e7. doi: 10.1016/j.molcel.2018.09.022. Epub 2018 Oct 25.},
	month = {Nov 1},
	pages = {444-456.e7},
	edition = {2018/11/08},
	abstract = {Skin sun exposure induces two protection programs: stress responses and pigmentation, the former within minutes and the latter only hours afterward. Although serving the same physiological purpose, it is not known whether and how these programs are coordinated. Here, we report that UVB exposure every other day induces significantly more skin pigmentation than the higher frequency of daily exposure, without an associated increase in stress responses. Using mathematical modeling and empirical studies, we show that the melanocyte master regulator, MITF, serves to synchronize stress responses and pigmentation and, furthermore, functions as a UV-protection timer via damped oscillatory dynamics, thereby conferring a trade-off between the two programs. MITF oscillations are controlled by multiple negative regulatory loops, one at the transcriptional level involving HIF1α and another post-transcriptional loop involving microRNA-148a. These findings support trait linkage between the two skin protection programs, which, we speculate, arose during furless skin evolution to minimize skin damage.},
	keywords = {*MITF dynamics, *skin pigmentation, *skin proliferation, *trait linkage, *UVB radiation, Animals, Cell Line, Humans, Hypoxia-Inducible Factor 1, alpha Subunit/physiology, Male, Melanocytes/physiology/radiation effects, Mice, Mice, Inbred C57BL, Microphthalmia-Associated Transcription Factor/*metabolism/radiation effects, MicroRNAs/physiology, Primary Cell Culture, Skin Pigmentation/radiation effects, Skin/*metabolism/*radiation effects, Ultraviolet Rays/adverse effects},
	isbn = {1097-2765 (Print)1097-2765},
	author = {Malcov-Brog, H. and Alpert, A. and Golan, T. and Parikh, S. and Nordlinger, A. and Netti, F. and Sheinboim, D. and Dror, I. and Thomas, L. and Cosson, C. and Gonen, P. and Stanevsky, Y. and Brenner, R. and Perluk, T. and Frand, J. and Elgavish, S. and Nevo, Y. and Rahat, D. and Tabach, Y. and Khaled, M. and Shen-Orr, S. S. and Levy, C.}
}
