@article {3173118,
	title = {Renal Mitochondrial ATP Transporter Ablation Ameliorates Obesity-Induced CKD},
	journal = {J Am Soc Nephrol},
	year = {2024},
	month = {2024 Jan 11},
	abstract = {<p>
	This study sheds light on the central role of adenine nucleotide translocase 2 (ANT2) in the pathogenesis of obesity-induced CKD. Our data demonstrate that ANT2 depletion in renal proximal tubule cells (RPTCs) leads to a shift in their primary metabolic program from fatty acid oxidation to aerobic glycolysis, resulting in mitochondrial protection, cellular survival, and preservation of renal function. These findings provide new insights into the underlying mechanisms of obesity-induced CKD and have the potential to be translated toward the development of targeted therapeutic strategies for this debilitating condition.
</p>
},
	issn = {1533-3450},
	doi = {10.1681/ASN.0000000000000294},
	author = {Permyakova, Anna and Hamad, Sharleen and Hinden, Liad and Baraghithy, Saja and Kogot-Levin, Aviram and Yosef, Omri and Shalev, Ori and Tripathi, Manish Kumar and Amal, Haitham and Basu, Abhishek and Arif, Muhammad and Cinar, Resat and Kunos, George and Berger, Michael and Leibowitz, Gil and Tam, Joseph}
}
